MovDisordV3, Main, Exploration, bibRecord, 003037

Accuracy of DaTSCAN (123I‐ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2‐Year follow‐up of an open‐label study

Identifieur interne : 003037 ( Main/Exploration ); précédent : 003036; suivant : 003038

Accuracy of DaTSCAN (123I‐ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2‐Year follow‐up of an open‐label study

Auteurs : Eduardo Tolosa [Espagne] ; Thierry Vander Borght [Belgique] ; Emilio Moreno [Espagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-12-15.

RBID : ISTEX:E984E7FFC5474D170AE5A102CEF9D3E00CC7C57C

Descripteurs français

Pascal (Inist)
- Cupule, Diagnostic, Homme, Ioflupane (123I), Parkinsonisme, Pathologie du système nerveux, Photon, Précision, Tomoscintigraphie émission monophotonique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Accuracy, Aged, CUPS, Cup, DAT, Diagnosis, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Follow-Up Studies, Human, Humans, Ioflupane (123I), Male, Middle Aged, Nervous system diseases, Nortropanes (diagnostic use), Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (radionuclide imaging), Parkinsonian Disorders (therapy), Parkinsonism, Photon, Radiopharmaceuticals (diagnostic use), Reproducibility of Results, SPECT, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon (methods), Treatment Outcome, diagnosis, parkinsonism.
MESH :
- chemical , diagnostic use : Nortropanes, Radiopharmaceuticals.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- diagnosis : Parkinsonian Disorders.
- methods : Tomography, Emission-Computed, Single-Photon.
- radionuclide imaging : Parkinsonian Disorders.
- therapy : Parkinsonian Disorders.
- Aged, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Reproducibility of Results, Treatment Outcome.

Abstract

We previously reported on the role of dopamine transporter (DAT) SPECT in the workup of patients with clinically uncertain parkinsonian syndromes (CUPS). The findings of that study supported the use of SPECT imaging with DaTSCAN (123I‐Ioflupane) for accurate diagnosis in this population. We report here the 2‐year follow‐up of the CUPS study, which aimed to validate the results of DaTSCAN imaging and to ascertain whether a second scan could minimize any residual diagnostic uncertainty among those with an inconclusive diagnosis. Eighty‐five of 118 patients (72%) were available at follow‐up. In 8 of 85 patients the neurologist was unable to provide a definite diagnosis (named as inconclusive). At follow‐up, clinical diagnosis agreed with initial DaTSCAN SPECT results in 69 of 77 patients (90%) in whom a specific diagnosis was established. A second SPECT scan was performed if clinical diagnosis at follow‐up differed to that suggested by the initial scan (n = 8) or was inconclusive (n = 8). Among 8 patients whose clinical diagnosis differed to DaTSCAN images, a second scan was performed in 6 (2 refused) and the results supported the final clinical diagnosis in 4. Follow‐up DaTSCAN SPECT helped to establish a diagnosis in 7 of 8 patients (87.5%) with a previously inconclusive diagnosis. DaTSCAN imaging shows a high rate of agreement with clinical diagnosis after 2‐years follow‐up. A second scan at 2 years follow‐up can reduce remaining diagnostic uncertainty that is present even after a prolonged period of observation. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/E984E7FFC5474D170AE5A102CEF9D3E00CC7C57C/fulltext/pdf

DOI: 10.1002/mds.21710

Affiliations:

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<term>Diagnosis, Differential</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
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<term>Follow-Up Studies</term>
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<term>Parkinsonism</term>
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<term>Reproducibility of Results</term>
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<term>Single photon emission tomography</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Treatment Outcome</term>
<term>diagnosis</term>
<term>parkinsonism</term>
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<front><div type="abstract" xml:lang="en">We previously reported on the role of dopamine transporter (DAT) SPECT in the workup of patients with clinically uncertain parkinsonian syndromes (CUPS). The findings of that study supported the use of SPECT imaging with DaTSCAN (123I‐Ioflupane) for accurate diagnosis in this population. We report here the 2‐year follow‐up of the CUPS study, which aimed to validate the results of DaTSCAN imaging and to ascertain whether a second scan could minimize any residual diagnostic uncertainty among those with an inconclusive diagnosis. Eighty‐five of 118 patients (72%) were available at follow‐up. In 8 of 85 patients the neurologist was unable to provide a definite diagnosis (named as inconclusive). At follow‐up, clinical diagnosis agreed with initial DaTSCAN SPECT results in 69 of 77 patients (90%) in whom a specific diagnosis was established. A second SPECT scan was performed if clinical diagnosis at follow‐up differed to that suggested by the initial scan (n = 8) or was inconclusive (n = 8). Among 8 patients whose clinical diagnosis differed to DaTSCAN images, a second scan was performed in 6 (2 refused) and the results supported the final clinical diagnosis in 4. Follow‐up DaTSCAN SPECT helped to establish a diagnosis in 7 of 8 patients (87.5%) with a previously inconclusive diagnosis. DaTSCAN imaging shows a high rate of agreement with clinical diagnosis after 2‐years follow‐up. A second scan at 2 years follow‐up can reduce remaining diagnostic uncertainty that is present even after a prolonged period of observation. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Accuracy of DaTSCAN (123I‐ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2‐Year follow‐up of an open‐label study

Accuracy of DaTSCAN (123I‐ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2‐Year follow‐up of an open‐label study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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